Independent Career

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Prior to Penn State

13.  Krishnamoorthy, L.,* Cotruvo, J.A., Jr.,* Chan, J., Kaluarachchi, H., Muchenditsi, A., Pendyala, V.S., Jia, S., Aron, A.T., Vander Wal, M.N., Guan, T., Smaga, L.P., Farhi, S.S., New, E.J., Lutsenko, S., and Chang, C.J. Copper regulates cyclic AMP-dependent lipolysis. Nat. Chem. Biol. 2016, 12, 586-592.  (*Denotes equal contribution)

12.  Aron, A.T., Ramos-Torres, K.M., Cotruvo, J.A., Jr., and Chang, C.J.  Recognition- and reactivity-based fluorescent probes for studying transition metal signaling in living systems.  Acc. Chem. Res. 2015, 48, 2434-2442.

11.  Cotruvo, J.A., Jr., Aron, A.T., Ramos-Torres, K.M., and Chang, C.J.  Synthetic fluorescent probes for studying copper in biological systems.  Chem. Soc. Rev. 2015, 44, 4400-4414.

10.  Cotruvo, J.A., Jr., Stich, T.A., Britt, R.D., and Stubbe, J.  Mechanism of assembly of the dimanganese-tyrosyl radical cofactor of class Ib ribonucleotide reductase: Enzymatic generation of superoxide is required for tyrosine oxidation via a Mn(III)Mn(IV) intermediate.  J. Am. Chem. Soc. 2013, 135, 4027-4039.

9.  Cotruvo, J.A., Jr. and Stubbe, J. Metallation and mismetallation of iron and manganese proteins in vitro and in vivo: the class I ribonucleotide reductases as a case study. Metallomics 2012, 4, 1020-1036. 

8.  Boal, A.K., Cotruvo, J.A., Jr., Stubbe, J., and Rosenzweig, A.C.  The dimanganese(II) site of Bacillus subtilis class Ib ribonucleotide reductase.  Biochemistry 2012, 51, 3861-3871.

7.  Cotruvo, J.A., Jr. and Stubbe, J.  Class I ribonucleotide reductases: Metallocofactor assembly and repair in vitro and in vivo.  Annu. Rev. Biochem. 2011, 80, 733-767.

6.  Cotruvo, J.A., Jr. and Stubbe, J.  Escherichia coli class Ib ribonucleotide reductase contains a dimanganese(III)-tyrosyl radical cofactor in vivo.  Biochemistry 2011, 50, 1672-1681.

5.  Stubbe, J. and Cotruvo, J.A., Jr.  Control of metallation and active cofactor assembly in the class Ia and Ib ribonucleotide reductases: diiron or dimanganese?  Curr. Opin. Chem. Biol. 2011, 15, 284-290.

4.  Boal, A.K., Cotruvo, J.A., Jr., Stubbe, J., and Rosenzweig, A.C.  Structural basis for activation of class Ib ribonucleotide reductase.  Science 2010, 329, 1526-1530.                                                                                                                           

3.  Cotruvo, J.A., Jr. and Stubbe, J.  An active dimanganese(III)-tyrosyl radical cofactor in Escherichia coli class Ib ribonucleotide reductase.  Biochemistry 2010, 49, 1297-1309.

2.  Cotruvo, J.A., Jr. and Stubbe, J.  NrdI, a flavodoxin involved in maintenance of the diferric-tyrosyl radical cofactor in Escherichia coli class Ib ribonucleotide reductase.  Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 14383-14388.

1.  Stubbe, J. and Cotruvo, J.A., Jr.  Ribonucleotide reductase: recent advances.  In Handbook of Metalloproteins, ed. A. Messerschmidt, Wiley (online).  2008, doi: 10.1002/0470028637.met229.  http://onlinelibrary.wiley.com/doi/10.1002/0470028637.met229/abstract.