Independent Career (corresponding authors underlined)

17. Featherston, E.R., Rose, H.R., McBride, M.J., E.M. Taylor, Boal, A.K., and Cotruvo, J.A., Jr. Biochemical and structural characterization of XoxG and XoxJ and their roles in activity of the lanthanide-dependent methanol dehydrogenase, XoxF. ChemBioChem 2019, accepted. [html] Featured in the ChemBioTalents issue and selected as a “Very Important Paper.”

16. Mattocks, J.A., Ho, J.V., and Cotruvo, J.A., Jr. A selective, protein-based fluorescent sensor with picomolar affinity for rare earth elements. J. Am. Chem. Soc. 2019, 141, 2857-2861. [html] Featured in a JACS Spotlight and a Penn State news story.

15. Cook, E.C., Featherston, E.R., Showalter, S.A., and Cotruvo, J.A., Jr. Structural basis for rare earth element recognition by Methylobacterium extorquens lanmodulin. Biochemistry, 2019, 58, 120-125. [html] Featured in C&E News and Nature Chemical Biology.

14. Cotruvo, J.A., Jr., Featherston, E.R., Mattocks, J.A., Ho, J.V., and Laremore, T.N. Lanmodulin: A highly selective lanthanide-binding protein from a lanthanide-utilizing bacterium. J. Am. Chem. Soc. 2018, 140, 15056-15061. [html] Featured in C&E News and Nature Chemical Biology.

Prior to Penn State

13.  Krishnamoorthy, L.,* Cotruvo, J.A., Jr.,* Chan, J., Kaluarachchi, H., Muchenditsi, A., Pendyala, V.S., Jia, S., Aron, A.T., Vander Wal, M.N., Guan, T., Smaga, L.P., Farhi, S.S., New, E.J., Lutsenko, S., and Chang, C.J. Copper regulates cyclic AMP-dependent lipolysis. Nat. Chem. Biol. 2016, 12, 586-592.  (*Denotes equal contribution)

12.  Aron, A.T., Ramos-Torres, K.M., Cotruvo, J.A., Jr., and Chang, C.J.  Recognition- and reactivity-based fluorescent probes for studying transition metal signaling in living systems.  Acc. Chem. Res. 2015, 48, 2434-2442.

11.  Cotruvo, J.A., Jr., Aron, A.T., Ramos-Torres, K.M., and Chang, C.J.  Synthetic fluorescent probes for studying copper in biological systems.  Chem. Soc. Rev. 2015, 44, 4400-4414.

10.  Cotruvo, J.A., Jr., Stich, T.A., Britt, R.D., and Stubbe, J.  Mechanism of assembly of the dimanganese-tyrosyl radical cofactor of class Ib ribonucleotide reductase: Enzymatic generation of superoxide is required for tyrosine oxidation via a Mn(III)Mn(IV) intermediate.  J. Am. Chem. Soc. 2013, 135, 4027-4039.

9.  Cotruvo, J.A., Jr. and Stubbe, J. Metallation and mismetallation of iron and manganese proteins in vitro and in vivo: the class I ribonucleotide reductases as a case study. Metallomics 2012, 4, 1020-1036. 

8.  Boal, A.K., Cotruvo, J.A., Jr., Stubbe, J., and Rosenzweig, A.C.  The dimanganese(II) site of Bacillus subtilis class Ib ribonucleotide reductase.  Biochemistry 2012, 51, 3861-3871.

7.  Cotruvo, J.A., Jr. and Stubbe, J.  Class I ribonucleotide reductases: Metallocofactor assembly and repair in vitro and in vivo.  Annu. Rev. Biochem. 2011, 80, 733-767.

6.  Cotruvo, J.A., Jr. and Stubbe, J.  Escherichia coli class Ib ribonucleotide reductase contains a dimanganese(III)-tyrosyl radical cofactor in vivo.  Biochemistry 2011, 50, 1672-1681.

5.  Stubbe, J. and Cotruvo, J.A., Jr.  Control of metallation and active cofactor assembly in the class Ia and Ib ribonucleotide reductases: diiron or dimanganese?  Curr. Opin. Chem. Biol. 2011, 15, 284-290.

4.  Boal, A.K., Cotruvo, J.A., Jr., Stubbe, J., and Rosenzweig, A.C.  Structural basis for activation of class Ib ribonucleotide reductase.  Science 2010, 329, 1526-1530.                                                                                                                           

3.  Cotruvo, J.A., Jr. and Stubbe, J.  An active dimanganese(III)-tyrosyl radical cofactor in Escherichia coli class Ib ribonucleotide reductase.  Biochemistry 2010, 49, 1297-1309.

2.  Cotruvo, J.A., Jr. and Stubbe, J.  NrdI, a flavodoxin involved in maintenance of the diferric-tyrosyl radical cofactor in Escherichia coli class Ib ribonucleotide reductase.  Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 14383-14388.

1.  Stubbe, J. and Cotruvo, J.A., Jr.  Ribonucleotide reductase: recent advances.  In Handbook of Metalloproteins, ed. A. Messerschmidt, Wiley (online).  2008, doi: 10.1002/0470028637.met229.  http://onlinelibrary.wiley.com/doi/10.1002/0470028637.met229/abstract.